Estrovera | Metagenics

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Testimonials practitioners

"Estrovera changes life for both patients and physicians."
~ R. Gulati, MD

"Most women notice a difference in their symptoms associated with menopause after two weeks to a month of treatment with Estrovera. For some women, the 'symptoms diminish to the point of' do not disturb at all, and other ' experiencing complete relief of all symptoms. Estrovera is a win-win situation, because it works and because there are no associated side effects. This product sells because it works!
"~ J . Cochran, ND

"Estrovera is comfortable, inexpensive and safe, and there is much anecdotal evidence that the product works for many women, while 'it is also effective. I think we should make changes in lifestyle and optimize health before exploring more risky options like hormone replacement therapies. As a doctor, I prefer to work on harmonization or encourage patients to optimize 'their lifestyle with diet and safe remedies . can alleviate their symptoms, or eliminate almost completely With Estrovera you 'does not have to be a seller or systematically encourage people to use it - they will come to you and you continue to ask, because it works!
"~ R. Lazarus, DC


Testimonials from patients

"This product DOES !! Even with treatment with bioidentical cream, my hot flashes were debilitating, exhausting and totally embarrassing. After three months of using Estrovera, hot flashes are occasionally instead of constantly arise ;. light rather than extreme 'tolerable rather than a torture I recently did an experiment by taking every other day, but I quickly discovered that I did not want to return to the country of torment.
"~ G. Lungle

"I have almost no hot flashes since I started taking this product!"
~ C. Babson

"Without Estrovera, I would live in the Arctic where I spend most of my days and my nights with the head in a freezer! So I'm not kidding! There are about five weeks, I started to take according Estrovera the recommendation of my naturopath, as a natural approach to treating my hot flashes. I struggled seriously for about five months, and hot flashes were just became unbearable and occurred almost every hour of the day or night. My heart beating at full speed and I could not 'sleep and I was just exhausted. I understand that after 44 years of rule, my body is confused and needs time to adjust to all this, but I 'was so tired and I felt ill and weak and ready to give and take the path of hormone replacement therapy. It will look like a commercial advertisement, but Estrovera helped me so much. My hot flashes are reduced to the point that I have about one every few hours, and their intensity is reduced by approximately 50%. I also take other vitamins to support my body in this phase change, I eat healthily and I avoid a lot of triggers. I can honestly say that without Estrovera, I would follow a hormone replacement therapy. I am so grateful for this natural support! I look forward to even more improvements over the coming months.
"~ P. Sheasby

"Before Estrovera, I had very significant hot flashes and extreme sweating every 45 minutes all day and all night. My shirt was soaked, my hair was soaked and I was' unable to sleep. After Estrovera first two weeks, I was able to sleep six hours away! Estrovera made ​​my life so much easier, and I feel so much cleaner now that I 'am no longer constantly sweating and dripping. It changed my hot flashes and my life and it finally allows me to have a good night ''s sleep.
"~ R. Hale, patient

"I'd say I'm perimenopausal, I have irregular cycles, mood swings and night sweats, which prevents me from sleeping. I started to find relief from my symptoms in about two weeks after the beginning of my treatment with Estrovera. Now I can sleep through the night and my mood is much more moderate. Estrovera is a product that all women at all stages of menopause may benefit, because it is healthy and that c is a simple solution that brings great positive results.
"~ D. Joy, patient



Estrovera provides effective relief for many symptoms associated with menopause, including hot flashes *

  • In a clinical trial of 12 weeks with 731 Err, women in perimenopause have reported significant improvements in their symptoms - including hot flashes and anxiety - in the space of just 28 days (compared to placebo ) * 3.4
  • In another clinical trial of 12 weeks, ERR 731 reduced the median number of daily hot flushes from 12 to 2 * 5
  • In a six-month trial, ERR 731 brought relief showed multiple symptoms measured by the Menopause Rating Scale (Menopause Rating Scale [MRS]), including * 1:

    • Negative mood, irritability, anxiety &
    • Joint and muscle discomfort
    • Physical or mental exhaustion
    • Sleeping troubles
    • Hot flashes / night sweats
  • In a study conducted over two years with Err 731, a reduction of about 83% of the MRS II total score was maintained for 60 weeks to 108 weeks * † 2
  • Estrovera provides a clinically effective dose of 731 Err in one tablet per day *

If you experience any side effects while using this product, please report it to Metagenics at 800-268-6200.


This estimated ratio is not included in the publication of the cumulative results of a 12-week test followed by two observational studies (EO) 48 weeks. It is calculated from the mean change in score of 5.7 MRS II at the end of the first 48 weeks of the EO divided by the benchmark score is 34. There is no change of score total between the end of the first EO and EO that of the second. These results only from the ERR subgroup 731, which were administered this compound daily for a total period of 108 weeks. This calculation does not take into account certain changes in the population studied over time.


Significant reduction in daily frequency of hot flashes *
Multiple short- and long-term studies with Err 731 (conducted with over 400 women in peri- and post-menopause) confirmed its effectiveness
in relieving symptoms associated with the menopause *

  • Well-designed clinical trials represent an unprecedented level of research approaches based phytoestrogens *
  • Two clinical trials phase III multicenter, randomized, double-blind, placebo-controlled (12 weeks)
  • Prospective study of six months, post-marketing surveillance study in 70 gynecological centers
  • Observational studies open to one and two years to demonstrate the efficacy and safety under long-term *

Comparable efficacy to hormonal therapies *

  • In just 12 weeks, ERR 731 is reduced by about 75% the median daily number of hot flashes * † 5
  • Similar to an average reduction of about 75% with hormonal therapies (TH) * 6
  • Significantly more effective than clinical results reported for many other natural products based phytoestrogens *
Scientific Chart

In a 12-week study of 109 perimenopausal women, subjects taking 731 ERR reported a significant decrease in median daily Nombe hot flashes compared to those taking placebo. * 5
Scientific Chart

For comparison, data were extrapolated from the placebo-controlled studies of various durations journals. 6.7
This estimated ratio is not included in the publication of the clinical study 12 week multicenter, randomized, placebo-controlled study, 112 postmenopausal women. It is calculated from the median change from day 9 flushing, divided by the median value of reference which was 12 daily hot flushes.


Err 731 has a long history *

  • Recommended by medical professionals in Germany since 1993
  • Numerous in vitro and in vivo studies on the metabolism and toxicology demonstrate a high degree of safety provided * 8-12
  • No clinically relevant change security settings - including gynecological observations, vital signs and laboratory safety parameters, is associated to treatment after 108 weeks of clinical observation * 2

Unlike hormonal therapy, ERR 731 contains no estrogen

  • The clinical benefits observed ERR 731 appear to be related to modulation of β unit of estrogen receptor (ER) as demonstrated in laboratory studies * 8-12
  • Siberian rhubarb is a vegetable, like its cousin - rhubarb (Rheum rhabarbarium)
  • All ERR 731 active ingredients are identified as hydroxystilbenes ( phytonutrients ), mainly rhaponticine
  • ERR 731 contains no anthraquinones, which are components of medicinal rhubarb traditionally used to treat occasional constipation, and which are of potential liver toxicity *
Safety Diagram

ERR 731 has a selective affinity for ERβ in the endometrial tissue, suggesting a safer approach. *


1. Kaszkin Bettag-M, Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract from Err 731 rhapontic rhubarb for menopausal complaints: a 6-month open observational study. [Efficacy of special extract of rhubarb rhapontique for symptoms associated with menopause: an observational study open from 6 months.] Altern Ther Health Med. 2008; 14 (6): 32-38.
2. Hasper I Ventskovskiy BM, Rettenberger R, et al. Long-term efficacy and safety of the special extract ERR 731 of Rheum Rhaponticum in perimenopausal women with menopausal symptoms. [Efficacy and long term safety of the special extract of Rheum Rhaponticum 731 Err in perimenopausal women with symptoms associated with menopause.] Menopause. 2009; 16 (1): 117-131. 3. Heger M, BM Ventskovskiy, Borzenko I, et al. Efficacy and safety of a special extract of Rheum Rhaponticum (Err 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. [Efficacy and safety of a special extract of Rheum Rhaponticum (Err 731) in perimenopausal women experiencing difficulties with the climacteric: 12-week trial randomized, double-blind, placebo-controlled] Menopause. 2006; 13 (5): 744-759. 4. Kaszkin Bettag-M, BM Ventskovsky, Kravchenko A, et al. The ERR 731 special extract of the roots of Rheum Rhaponticum decreases anxiety and Improves general health state and well-being in perimenopausal women. [Err 731 The special extract of the roots of Rheum Rhaponticum lowers anxiety and improves the state of health and well-being among perimenopausal women] Menopause. 2007; 14 (2): 270-283. 5. Kaszkin Bettag-M, BM Ventskovsky, Solskyy S, et al. Confirmation of the efficacy of Err in 731 perimenopausal women with menopausal symptoms. [Confirmation of the effectiveness of Err 731 perimenopausal women with symptoms associated with menopause] Altern Ther Health Med. 2009; 15 (1): 24-34. 6. Maclennan AH, Broadbent JL, Lester S, Moore V. Oral estrogen and combined estrogen / progestogen therapy versus placebo for hot flushes. [Estrogen and oral combination therapy with estrogen / progestogen versus placebo for hot flashes] Cochrane Database Syst Rev. 2004; (4): CD002978. 7. P. Albertazzi Menopause: alternative to estrogen manages to hot flushes. [Alternatives to estrogen for the treatment of hot flashes] Gynecol Endocrinol. 2005; 20 (1): 13-21. 8. Papke A, G Kretzschmar, Zierau O, Kaszkin Bettag-M, Vollmer G. Effects of the special extract from Err 731 Rheum Rhaponticum is estrogen-regulated targets in the model of ovariectomized rats uterotrophy. [Effects of special extract of Rheum Rhaponticum 731 Err on target regulated by estrogen in the utérotrophie model of ovariectomized rats] J Steroid Biochem Mol Biol. 2009; 17 (4-5): 176-184. 9. Kaszkin Bettag-M, Richardson A, R Rettenberger, Heger PW. Long-term toxicity studies in dogs supporting the safety of the special extract ERR 731 from the roots of Rheum Rhaponticum. [Long-term toxicity studies in dogs support the safety of ERR 731 special extract of the roots of Rheum Rhaponticum] Food Chem Toxicol. 2008; 46 (5): 1608-1618. 10. Wober J, Möller F, Richter T, et al. Activation of estrogen receptor-beta by a special extract of Rheum Rhaponticum (Err 731), ict and aglycone Structurally related compounds. [Activation of the beta subunit of the estrogen receptor by a special extract of Rheum rhaponticum (ERR 731), its aglycone and structurally related compounds] J Steroid Biochem Mol Biol. 2007; 107 (3-5): 191-201. 11. Möller F, O Zierau, Jandausch A, R Rettenberger, Kaszkin Bettag-M, G. Vollmer Subtype-specific activation of estrogen receptors by a special extract of Rheum Rhaponticum (Err 731), ict and aglycone Structurally related compounds in human osteosarcoma cells U2OS . [Activation subtype-specific estrogen receptor by a special extract of Rheum Rhaponticum (Err 731), its aglycone and structurally related compounds in human osteosarcoma cells U2OS] Phytomedicine. 2007; 11: 716-726. 12. Keiler AM, Papke A, G Kretzschmar, Zierau O, Vollmer G. Long-term effects of the rhubarb extract rhapontic Err 731 is estrogen-regulated targets in the uterus and on the bone in ovariectomized rats. [Long-term effects of rhubarb extract rhapontique 731 Err on target regulated by estrogen in the uterus and bones of ovariectomized rats] J Steroid Biochem Mol Biol. 2012; 128 (1-2): 62-68.